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  • Full description:
  • Cipro-Denk 750 contains the active substance Ciprofloxacin is an antibiotic belonging to the fluoroquinolone group. Ciprofloxacin works by killing bacteria that cause infections. It only works in certain strains of bacteria.
  • Adults
  • Cipro-Denk 750 is used in adults to treat the following bacterial infections:
  • certain respiratory tract infections
  • certain forms of ear or sinus inflammations
  • urinary tract infections
  • infections of the male and female genitalia
  • infections of the gastrointestinal tract and infections of the abdominal cavity
  • certain skin and soft-tissue infections
  • infections of the bones and joints
  • to prevent infections caused by the bacterium Neisseria meningitidis
  • treatment after inhalation of anthrax pathogens
  • Ciprofloxacin may be used in the management of patients with a low number of certain white blood cells (neutropenia) and fever and that is suspected to be due to a bacterial infection.
  • If you have a severe infection or an infection caused by several types of bacteria, you may be given other antibiotic treatment in addition to Cipro-Denk 750.
  • Children and adolescents
  • Cipro-Denk 750 is used in children and adolescents, under the supervision of a specialist doctor, to treat the following bacterial infections:
  • lung and bronchial infections in children and adolescents suffering from cystic fibrosis
  • complicated urinary tract infections, including infections involving the renal pelvis (acute pyelonephritis)
  • treatment after inhalation of anthrax pathogens
  • What Cipro-Denk 750 contains:
  • The active substance is ciprofloxacin. Each film-coated tablet contains 750 mg ciprofloxacin (as ciprofloxacin hydrochloride).
  • The other ingredients are: sodium starch glycolate (type A), low-substituted hydroxypropyl cellulose, magnesium stearate [vegetable], hypromellose, macrogol 400, titanium dioxide, talc.
  • Possible side effects:
  • Like all medicines, this medicine can cause side effects, although not everybody gets them. The following section contains the most serious side effects that you can recognize yourself: Stop taking Cipro-Denk 750 and contact your doctor immediately in order to consider another antibiotic treatment if you notice any of the following serious side effects.
  • Rare (may affect up to 1 in 1,000 people):
  • –seizure (see section 2 “Warnings and pre¬cautions”)
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  • Very rare (may affect up to 1 in 10,000 people):
  • –severe, sudden allergic reaction with symptoms such as tightness in the chest, feeling dizzy, sick or faint, or experience dizziness when standing up (anaphylactic reaction/ shock) (see section 2 “Warnings and precautions”)
  • –muscle weakness, inflamed tendons, tendon rupture – especially of the large tendon at the back of the ankle (Achilles tendon) (see section 2 “Warnings and precautions”)
  • –a serious life-threatening skin rash, usu¬ally in the form of blisters or ulcers in the mouth, throat, nose, eyes and other mucous membranes such as genitals which may progress to widespread blistering or peeling of the skin (Stevens-Johnson syndrome, toxic epidermal necrolysis)
  • Not known (frequency cannot be estimated from the available data):
  • –unusual feelings of pain, burning, tingling, numbness or muscle weakness in the extremities (neuropathy) (see section 2 “Warnings and precautions”)
  • –a drug reaction that causes rash, fever, inflammation of internal organs, hemato¬logic abnormalities and systemic illness (DRESS Drug Reaction with Eosinophilia and Systemic Symptoms, AGEP Acute Generalised Exanthematous Pustulosis)
  • Other side effects which have been observed during treatment with ciprofloxacin are listed below by how likely they are.
  • Common (may affect up to 1 in 10 people):
  • nausea, diarrhoea
  • joint pain and joint inflammation in children
  • Uncommon (may affect up to 1 in 100 people):
  • joint pain in adults
  • fungal superinfections
  • high concentration of eosinophil granulocytes, certain white blood cells
  • decreased appetite
  • hyperactivity or restlessness
  • headache, light-headedness, sleeping or taste disorders
  • vomiting, stomach ache, digestive disorders such as upset stomach (feeling full/heartburn) or wind
  • increase in certain substances in the blood (transaminases and/or bilirubin)
  • rash, itching or nettle rash
  • kidney dysfunction
  • muscle and bone pain, generally feeling unwell (asthenia) or fever
  • increase in blood alkaline phosphatase (a certain substance in the blood)
  • Rare (may affect up to 1 in 1,000 people):
  • muscle pain, inflamed joints, increased muscle tension or cramps
  • inflammation of the large bowel lining triggered by antibiotics (colitis), very rarely with a fatal outcome (see section 2 “Warnings and precautions”)
  • changes in the blood count (leukocytopenia, leukocytosis, neutropenia, anaemia), decrease or increase in a certain blood coagulation factor (platelets)
  • allergic reaction, swelling (oedema) or rapid swelling of the skin and mucous membranes (angioedema) (see section 2 “Warnings and precautions”)
  • increase in blood sugar (hyperglycaemia)
  • decreased blood sugar (hypoglycaemia) (see section 2 “Warnings and precautions”)
  • confusion, disorientation, anxiety, nightmares, depressions (potentially leading to suicidal thoughts, suicide attempts or completed suicide) or hallucinations
  • tingling, unusual sensitivity to sensory stimuli, reduced sensitivity of the skin, tremor or
  • dizziness
  • visual disturbances, including double vision
  • ringing in the ears (tinnitus) or hearing loss or reduced hearing
  • racing heart (tachycardia)
  • widening of the blood vessels (vasodilation), low blood pressure or fainting
  • shortness of breath, including asthmatic symptoms
  • liver dysfunction, jaundice (bile accumulation) or liver inflammation
  • sensitivity to light (see section 2 “Warnings and precautions”)
  • kidney failure, blood or crystals in the urine, inflammation of the urinary tract
  • fluid retention or excessive sweating
  • increased levels of the amylase enzyme
  • Very rare (may affect up to 1 in 10,000 people):
  • a special type of reduced red blood cell count (haemolytic anaemia), a dangerous decrease in certain white blood cells (agranulocytosis) possibly life-threatening decrease in certain red and white blood cells and platelets (pancytopenia) and reduced bone marrow function, which can also be life-threatening
  • allergic reaction called serum sickness-like reaction
  • psychiatric disorders (psychotic reactions, potentially leading to suicidal thoughts, suicide attempts or a completed suicide)
  • migraine, impaired coordination, unsteady walking (impaired gait), impaired sense of smell (olfactory disorder), pressure on the brain (intracranial pressure and pseudotumor cerebri)
  • problems in colour vision
  • inflammation of the blood vessel walls (vasculitis)
  • inflammation of the pancreas (pancreatitis)
  • liver cell death (liver necrosis), very rarely progressing to life-threatening liver failure
  • small, pinpoint bleeding into the skin (petechiae); various skin changes and types
  • of rash
  • worsening of myasthenia gravis symptoms
  • Not known (frequency cannot be estimated from the available data):
  • feeling highly excited (mania) or feeling great optimism and overactivity (hypomania)
  • abnormal fast heart rhythm, life-threatening irregular heart rhythm, alteration of the heart rhythm (called “prolongation of QT interval”, seen on ECG, electrical activity of the heart)
  • impairment of blood clotting (in patients, treated with vitamin K antagonists)
  • syndrome associated with impaired water excretion and low levels of sodium (SIADH)
  • loss of consciousness due to severe decrease in blood sugar levels (hypoglycaemic coma).
  • Very rare cases of long lasting (up to months or years) or permanent adverse drug reactions, such as tendon inflammations, tendon rupture, joint pain, pain in the limbs, difficulty in walking, abnormal sensations such as pins and needles, tingling, tickling, burning, numbness or pain (neuropathy), depression, fatigue, sleep disorders, memory impairment, as well as impairment of hearing, vision, and taste and smell have been associated with administration of quinolone and fluoroquinolone antibiotics, in some cases irrespective of pre-existing risk factors.
  • Cases of an enlargement and weakening of the aortic wall or a tear in the aortic wall (aneurysms and dissections), which may rupture and may be fatal, and of leaking heart valves have been reported in patients receiving fluoroquinolones.
  • How to take:
  • Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Your doctor will explain to you exactly how much Cipro-Denk 750 to take, as well as how often and for how long. This will depend on the type and severity of the infection that you have.
  • Please tell your doctor if you suffer from kidney problems, as your dose may have to be adjusted. Treatment usually lasts for 5 to 21 days, but may be longer for severe infections. Always take this medicine exactly as your doctor has told you. Take the film-coated tablets whole (not chewed) with plenty of liquid. You should not chew the film-coated tablets due to their unpleasant taste.
  • The score line is only there to help you break the tablet if you have difficulty swallowing it whole. Wherever possible, try to take Cipro-Denk 750 at roughly the same time each day. You can take Cipro-Denk 750 with a meal or independently of meals. Absorption of the active substance is only marginally affected by a meal containing calcium. However, do not take Cipro-Denk 750 with dairy products, such as milk or yoghurt, or with mineral-enriched drinks (e.g. calcium-enriched orange juice). Please make sure that you drink sufficient liquid during treatment with Cipro-Denk 750.
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