Full description:
Doxy-Denk 100 is a medicine (antibiotic) from the tetracycline group. Doxycycline works by preventing the growth and spread of bacteria that cause infections in your body and which are sensitive to doxycycline.
What Doxy-Denk 100 contains:
- The active substance is doxycycline hyclate. Each tablet contains 115.4 mg doxycycline hyclate, equivalent to 100 mg doxycycline.
- The other ingredients are: Sodium starch glycolate, maize starch, hydrogenated castor oil, lactose monohydrate, silica colloidal anhydrous, magnesium stearate, microcrystalline cellulose.
Possible side effects:
The following side effects have been observed with tetracyclines (a group of antibiotics, which includes doxycycline).
If you experience any of the side effects listed below, consult your doctor immediately:
- Sudden onset of severe rash or blistering or skin peeling with fever and joint pain (see 2.“Warnings and precautions“).
- Severe allergic reaction accompanied by sudden and increasing shortness of breath, swelling in the head region (swollen tongue, swollen larynx) and body, rash, blood circulation disorders, drop in blood pressure, unconsciousness (see 2.“Warnings and precautions“).
- Severe, persistent watery or bloody diarrhoea with abdominal pain or fever (see 2.“Warnings and precautions“).
- The Jarisch-Herxheimer reaction which causes fever, chills, headache, muscle pain and skin rash that is usually self-limiting. This occurs shortly after starting doxycycline treatment for infections with spirochete
such as Lyme disease.
Possible side effects
Very common (may affect more than 1 in 10 people)
- Phototoxic reactions due to light sensitivity (redness,swelling, blistering)
Common (may affect up to 1 in 10 people)
- Allergic (hypersensitivity) reactions (often accompanied by a drop in blood pressure, dizziness, nausea and possibly shortness of breath) including inflammation of the small blood vessels (Henoch-Schonlein purpura), inflammation of the sac surrounding the heart (pericarditis), allergic, painful swelling of the skin and mucous membranes, especially in the facial area (angioedema), worsening of systemic lupus erythematosus, asthma, serum sickness, swelling of ankles/lower legs due to water retention, faster
heartbeat/racing heart, hives
- Headache
- Nausea, vomiting, bloating, fatty stools
- Rash, including maculopapular rash (small flat spots and/or raised spots on the skin), erythematous (reddened)
rash and large scaly rash.
Uncommon (may affect up to 1 in 100 people)
- Blood coagulation disorders
- Gastrointestinal disorders (heartburn, inflammation of the mucosal lining of the stomach), inflammation of the mucosal lining of the mouth and throat, hoarseness, black hairy tongue, permanent discolouration of the teeth and damage to the tooth enamel when used during tooth formation
- Delayed bone growth when used during pregnancy or in children under 8 years of age
- Blood in the urine
Rare (may affect up to 1 in 1,000 people)
- Changes in the blood picture (sharp decrease in platelets, anaemia due to disintegration of red blood cells, changes in the number, shape and function of white blood cells), abnormal swelling of the lymph nodes
- Circulatory collapse and/or shortness of breath (anaphylactic shock), severe hypersensitivity reaction to medication use (DRESS syndrome)
- Loss of appetite
- Restlessness, anxiety
- Increased pressure on the brain in adults (possible signs are headache, nausea, vomiting, papilloedema and visual disturbances, e.g. double vision), nerve damage that may manifest as numbness, pain, tingling or burning sensation of the hands or feet, impairment or loss of the sense of smell and taste
- Ringing in the ears
- Flushing
- Diarrhoea due to antibiotics, inflammation of the colon lining (large bowel), inflammation and ulcers of the oesophagus (gullet), inflammatory changes (with Candida infection) in the anogenital region (inflammation of the external genitalia in women and anal itching), abdominal pain, diarrhoea, difficulty swallowing, tongue inflammation
- Liver damage, inflammation of the liver, increased liver function tests, inflammation of the pancreas
- Severe skin reactions, sometimes involving the mucous membranes (erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome) and tissue detachment (toxic epidermal necrolysis), detachment and discolouration of the nails
- Muscle pain, joint pain
- Increased blood urea nitrogen (BUN) levels
Very rare (may affect up to 1 in 10,000 people)
- Seizures
- Temporary short-sightedness
- Kidney damage (interstitial nephritis, acute kidney failure, failure to produce urine)
Not known (frequency cannot be estimated from the available data)
- Microscopic brownish-black discolouration of the thyroid (with no confirmed pathological value)
- Discolouration and/or lack of growth of teeth
How to use:
Doxy-Denk 100 should be taken regularly, either in the mornings with breakfast or with another meal.
By taking the medicine with meals, the frequency of gastrointestinal disorders can be reduced. In order to prevent the development of ulcers in the mucous lining of the oesophagus, Doxy-Denk 100 should be taken together with plenty of liquid (not milk or milk products), e.g. a glass of water whilst upright (sitting or standing) ), and should not be taken immediately before going to bed. About 10-15 minutes after taking the medicine, drink another generous amount of fluid!
The dosage and duration of treatment will be decided by your doctor and will depend on, among other things, the severity and site of infection.
