Full description:
Nifedi-Denk 20 Retard contains the active substance nifedipine. Nifedi-Denk 20 Retard is used in the treatment of cardiac complaints, which are associated with insufficient oxygen supply to the heart muscle (angina pectoris), and in the treatment of hypertension.
Nifedi-Denk 20 Retard is used for:
- complaints (e.g. pain or tightness in the chest) in conditions with an inadequate supply of oxygen to the heart muscle during exertion: chronic stable angina pectoris (effort angina)
- vasospastic angina pectoris (Prinzmetal’s angina, variant angina)
- non-organ-related high blood pressure (essential hypertension).
What Nifedi-Denk 20 Retard contains:
- The active substance is nifedipine. Each prolonged-release tablet contains 20 mg nifedipine.
- The other ingredients are: microcrystalline cellulose, maize starch, lactose monohydrate, polysorbate 80, magnesium stearate [vegetable], hypromellose, macrogol 6000, talc, titanium dioxide, red ferric oxide.
Possible side effects:
Very common
Headaches, peripheral oedema (due to vasodilatation).
Common
Dizziness, somnolence, feeling of weakness, palpitations, flushing, constipation, nausea, erythromelalgia (particularly at the commencement of treatment), sweating, malaise.
Uncommon
Allergic reactions, allergic tissue swelling, swelling of the face and mucosa (angiooedema), including swelling of the larynx (laryngeal oedema) which may be life-threatening. Pruritis, exanthema, anxiety, sleeping disorders, migraine, tremor, paraesthesia (e.g. tingling, furry feeling), possibly also painful. Tiredness/drowsiness, nervousness, impaired vision, tachycardia, hypotension, syncopes, epistaxis, blocked nose, dyspnoea, gastrointestinal disorders, tummy-ache, dyspepsia, flatulence, dryness of mouth, liver enzyme elevations, reddening of the skin with a warm feeling, muscle cramps, swollen joints, myalgia, increased urgency of urination as well as increased daily urination, painful urge to urinate with difficulty in passing water. In cases of renal insufficiency, transient deterioration in renal function, erectile disorders, unspecific pain, shivering.
Particularly at the beginning of treatment there may be episodes of angina pectoris, and in patients already suffering from angina pectoris nifedipine may increase its frequency, duration and severity.
Rare
Changes in blood count, such as anaemia, leukopenia, thrombopenia, thrombocytopenic purpura, urticaria, hyperglycaemia, gingival hyperplasia, anorexia, sensation of fullness, burping, jaundice, photodermatitis, purpura, gynaecomastia, which is reversible after discontinuation of nifedipine.
Very rare
Agranulocytosis, myocardial infarction, exfoliative dermatitis. Frequency not known Anaphylactic/anaphylactoid reactions, hypoaesthesia, asthenopia, shortness of breath, vomiting, oesophagitis, toxic epidermal necrolysis, arthralgia. Dialysis patients with high blood pressure and a low blood volume may experience a sudden drop in blood pressure.
How to take:
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. Treatment should as far as possible be administered individually on the basis of the severity of the condition and the patient’s response.
The target dose should be reached gradually, depending on the medical condition concerned. The dose of Nifedi-Denk 20 Retard may need to be adjusted if you are concurrently taking other medicines that inhibit or potentiate a specific enzyme system.
Nifedi-Denk 20 Retard is suitable for patients with high blood pressure, who suffer from severe cerebrovascular disease, and for those, where an excessive reaction to nifedipine can be expected because of low body weight or because of concomitant treatment with other blood pressure reducing medicines.
Patients whose side effects to the nifedipine treatment would seem to make a more subtle adjustment of the dosage level desirable should also have the dose of Nifedi-Denk 20 Retard adapted individually.
It is recommended to leave an interval of 12 hours, but no less than 4 hours, between single doses of Nifedi-Denk 20 Retard.
