Full description:
Amva Denk contains two substances, amlodipine and valsartan. Both of these substances are used to control high blood pressure.
- Amlodipine belongs to a group of sub-stances called “calcium channel blockers”. Amlodipine stops calcium from moving into the blood vessel wall which stops the blood vessels from tightening.
- Valsartan belongs to a group of substanc-es called “angiotensin Il receptor antago- nists”. Angiotensin Il is produced by the body and makes the blood vessels tight-en, thus increasing the blood pressure.
This means that both of these substances help to stop the blood vessels tightening. As aresult, the blood vessels relax and blood pressure is lowered.
Amva Denk is used to treat high blood pressure in adults whose blood pressure is not controlled enough with either amlodipine or valsartan on its own.
What Amva-denk 5/80 contains:
The active substances are amlodipine (asbesilate) and valsartan. Each film-coated tablet contains 5 mg amlodipine and 80 mg valsartan.
The other ingredients are microcrys-talline cellulose, povidone (K-29/32), croscarmellose sodium, talc, magnesium stearate [vegetable], hypromellose, titanium dioxide, iron oxide yellow, macrogol 400.
Possible side effects:
Like all medicines, this medicine can cause side effects, although not everybody gets
them.Some side effects can be serious and need immediate medical attention:
A few patients have experienced these serious side effects (may affect up to 1 in 1,000
people). If any of the following happen,tell your doctor straight away:
Allergic reaction with symptoms such as rash, itching, swelling of face or lips or
tongue, difficulty breathing, low bloodpressure (feeling of faintness, light-headedness). Other possible side effects of
Amva Denk:
Common (may affect up to 1 in 10 peo-ple): Influenza (flu); blocked nose, sore throat and discomfort when swallowing; headache; swelling of arms, hands, legs,ankles or feet; tiredness; asthenia (weakness); redness and warm feeling of the face and/or neck.
Uncommon (may affect up to 1 in 100 people): Dizziness; nausea and abdominal pain;
dry mouth; drowsiness, tingling or numbness of the hands or feet; vertigo; fast heart beat including palpitations; dizziness on standing up; cough; diarrhoea; constiption; skin rash, redness of the skin; joint swelling, back pain; pain in joints.
Rare (may affect up to 1 in 1,000 people):
Feeling anxious; ringing in the ears (tinnitus); fainting; passing more urine than normal or feeling more of an urge to passurine; inability to get or maintain an erection; sensation of heaviness; low blood pressure with symptoms such as dizziness, light-headedness; excessive sweating; skin rash all over your body; itching;muscle spasm. If any of these affect you severely, tell your doctor.
Side effects reported with amlodipine or valsartan alone and either not observed with the combination of both or observed with a higher frequency than with the combination:
Amlodipine
Consult a doctor immediately if you experience any of the following very rare, severe side effects after taking this medicine:
Sudden wheeziness, chest pain, shortness of breath or difficulty in breathing.
« Swelling of eyelids, face or lips.
« Swelling of the tongue and throat which causes great difficulty breathing.
Severe skin reactions including intense skin rash, hives, reddening of the skin over your whole body, severe itching, blistering, peeling and swelling of the skin, inflammation of the mucous membranes (Stevens-Johnson Syndrome, toxic epidermal necrolysis) or other allergic reactions.
Heart attack, abnormal heart beat.
Inflamed pancreas, which may cause severe abdominal and back pain accompanied with feeling of being very unwell.
The following side effects have been reported. If any of these cause you problems or if they last for more than one week, you should contact your doctor.
Common (may affect up to 1 in 10 people):
Dizziness, sleepiness; palpitations (awareness of your heart beat); flushing, ankle swelling (oedema); abdominal pain, feeling sick (nausea).
Uncommon (may affect up to 1in 100 people):
Mood changes, anxiety, depression, sleeplessness, trembling, taste abnormalities;fainting, loss of pain sensation; visual disturbances, visual impairment, ringing in the ears; low blood pressure; sneezing/runny nose caused by inflammation of the lining of the nose (rhinitis); indigestion,vomiting (being sick); hair loss, increased sweating, itchy skin, skin discolouration; disorder in passing urine, increased need to urinate at night, increased number of times of passing urine; inability to obtain an erection, discomfort or enlargement of the breasts in men, pain, feeling unwell, muscle pain, muscle cramps; weight increase or decrease.
Rare (may affect up to 1 in 1,000 people): Confusion.
Very rare (may affect up to 1 in 10,000 people):
Decreased number of white blood cells, decrease in blood platelets which may result in unusual bruising or easy bleeding (red blood cell damage); excess sugar in blood (hyperglycaemia); swelling of the gums, abdominal bloating (gastritis); abnormal liver
function, inflammation of the liver (hepatitis), yellowing of the skin (jaundice), liver enzyme increase which may have an effect on some medical tests; increased muscle tension; inflammation of blood vessels often with skin rash, sensitivity to light; disorders combining rigidity, tremor and/or movement disorders.
Not known (frequency cannot be estimated from the available data):
Trembling, rigid posture, mask-like face, slow movements and a shuffling, unbalanced walk.
Valsartan
Not known (frequency cannot be estimated from the available data): Decrease in red blood cells, fever, sore throat or mouth sores due to infections; spontaneous bleeding or bruising; high level of potassium in the blood; abnormal liver test results; decreased renal functions and severely decreased renal functions;
swelling mainly of the face and the throat; muscle pain; rash, purplish-red spots; fever; itching; allergic reaction; blistering skin (sign of a condition called dermatitis bullous).
How to take:
Always take this medicine exactly as your doctor has told you. Check with your doctor if you are not sure. This will help you get the best results and lower the risk of side effects. The usual dose of Amva Denk 5/80 mg is one film-coated tablet per day.
- It is preferable to take your medicine at the same time each day.
- Swallow the film-coated tablet with a glass of water.
- You can take Amva Denk with or without food. Do not take Amva Denk with grapefruit or grapefruit juice.
Depending on how you respond to the treatment, your doctor may suggest a higher or lower dose. Do not exceed the prescribed dose.
